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June 2002

Clinical and In Vitro Responses of Bilayered Skin Construct (Graftskin) to Meshing

Author Affiliations

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Arch Dermatol. 2002;138(6):843-844. doi:10.1001/archderm.138.6.838

Graftskin (Apligraf; Novartis Pharmaceuticals Corporation, East Hanover, NJ), a bilayered living skin construct, is approved in the United States for venous ulcers and diabetic foot ulcers.1-3 Studies suggest that Graftskin may also heal excisional wounds.4 Graftskin is approximately 0.075-cm thick, so it is structurally similar to a split-thickness skin graft. Graftskin can be meshed for better adherence to exudative wounds. Meshing of skin grafts may also promote healing by increasing dermal exposure to underlying tissue.5 Although Graftskin is frequently meshed in the clinical setting, there is little information as to how this affects the tissue. We examined the effects of manipulating and meshing Graftskin on its structural integrity and viability.

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