This is a 401-page book devoted to the study of systemic processes in which there is significant cutaneous involvement, with particular emphasis on the description of histologic features. The authors classify those diseases in 7 parts: I, diseases involving skin and multiple internal organs; II, diseases involving the skin and limited internal organs; III, metabolic and storage; IV, infectious diseases; V, drug-induced diseases; VI, internal malignancies; and VII, pediatric diseases. Within each part, diseases are further organized into easily recognizable groups such as cardiac, renal, or musculoskeletal diseases. Regarding each disease, there is a description of epidemiology, clinical cutaneous features, associated disorders, histologic features, special studies, and etiopathogenesis.