Treating patients for alopecia areata (AA) in its universal form is a difficult task. Topical immunotherapy, methylprednisolone pulse therapy, or psoralen–UV-A, which are proposed for other severe forms of this disease, often have no effect in patients with universal AA. The exact pathogenesis of the disorder is still not known; however, there is growing evidence of a transient, reversible, and tissue-restricted autoimmune process.1
Friedli A, Prins C, Chavaz P, Saurat JH. Unsuccessful Treatment of Alopecia Areata Universalis With Extracorporeal Photopheresis. Arch Dermatol. 2002;138(8):1103–1104. doi:10.1001/archderm.138.8.1098
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