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August 2002

Unsuccessful Treatment of Alopecia Areata Universalis With Extracorporeal Photopheresis

Author Affiliations

Not Available

Arch Dermatol. 2002;138(8):1103-1104. doi:10.1001/archderm.138.8.1098

Treating patients for alopecia areata (AA) in its universal form is a difficult task. Topical immunotherapy, methylprednisolone pulse therapy, or psoralen–UV-A, which are proposed for other severe forms of this disease, often have no effect in patients with universal AA. The exact pathogenesis of the disorder is still not known; however, there is growing evidence of a transient, reversible, and tissue-restricted autoimmune process.1