The article titled "Tazarotene Cream for the Treatment of Facial Photodamage" in the December 2001 issue of the ARCHIVES1 is far removed from the standards of evidence-based medicine. There are missing data, numerical juggling, and selective reporting of data.
In the authors' summary, percentage success rates are based on "global response," a measure that involved the investigator's memory. At each visit, evaluators compared the subject's condition with their recall of the subject's appearance at baseline and scored this on a 7-point scale. Is it realistic to expect an investigator to remember what the subject's skin looked like 6 months ago?
Epstein E. Questionable Techniques for Evaluating Photodamage. Arch Dermatol. 2002;138(11):1515. doi:10.1001/archderm.138.11.1515
Dermatology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.