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November 2002

Improvement of Chronic Generalized Granuloma Annulare With Isotretinoin

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Arch Dermatol. 2002;138(11):1518. doi:10.1001/archderm.138.11.1515

Generalized granuloma annulare (GGA) is a chronic skin condition of unknown origin frequently with significant aesthetic impairment. It has been considered as a disseminated form of localized granuloma annulare (GA) affecting at least the trunk and upper and/or lower extremities.1 Treatment modalities for localized GA such as intralesional corticosteroid injections and cryotherapy are impractical for treating large areas of the body. Few reports document the effectiveness of isotretinoin in the treatment of GGA. We report a case of chronic (34 years' duration) GGA that demonstrated a 90% improvement with oral isotretinoin therapy.

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