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Evidence-Based Dermatology: Research Commentary
December 2002

Should Pentoxifylline Be Used as an Adjuvant for the Treatment of Venous Leg Ulcer?

Author Affiliations

MichaelBigbyMDRosamariaCoronaDSc, MDDamianoAbeniMD, MPHPaoloPaolo PasquiniMD, MPHMoysesSzkloMD, MPH, DrPHHywelWilliamsMD

Arch Dermatol. 2002;138(12):1597-1598. doi:10.1001/archderm.138.12.1597

Question: What is the effect of pentoxifylline on the healing of venous leg ulcer?

Data Sources: The CENTRAL registers of the Cochrane Wounds Group and the Cochrane Peripheral Vascular Diseases Group. The authors also contacted Aventis Pharma France to obtain unpublished studies.

Studies: Studies were selected for inclusion if they were randomized clinical trials and reported either the percentage of change in ulcer area, percentage of ulcers healed, or percentage ulcer improvement of the patients' primary reference ulcer. Studies of all languages were included for analysis.