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December 2002

Mycosis Fungoides and Follicular Mucinosis

Author Affiliations

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Arch Dermatol. 2002;138(12):1613. doi:10.1001/archderm.138.12.1613

In the February issue of the ARCHIVES, Cerroni et al1 compared 16 patients with follicular mucinosis (FM) occurring without mycosis fungoides (MF) with 28 patients with FM occurring in the setting of MF. These authors found that there was a considerable overlap in the histological features, molecular analyses, and clinical presentation between these 2 presentations of FM, and they concluded that idiopathic FM may represent a variant of localized MF. In an accompanying editorial, Sangüeza and Lu2 praised this work and appeared to agree with the conclusion that many FM are low-grade cutaneous T-cell lymphomas from the onset. In my opinion, analysis of the authors' reported data on outcomes for their 44 patients suggest a different conclusion, namely, that idiopathic FM and FM associated with MF are distinct diseases with different outcomes.

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