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Evidence-Based Dermatology: Research Commentary
March 2003

Taking Advantage of a Side Effect of Isotretinoin

Author Affiliations

MichaelBigbyMDRosamariaCoronaDSc, MDDamianoAbeniMD, MPHPaoloPasquiniMD, MPHMoysesSzkloMD, MPH, DrPHHywelWilliamsMSc, PhD, FRCP

Arch Dermatol. 2003;139(3):376-377. doi:10.1001/archderm.139.3.376

Question: Do young adults who develop hypertriglyceridemia after isotretinoin therapy for acne have an inherited predisposition to develop familial combined hyperlipidemia (FCHL) and the metabolic syndrome?

Objective: To explore the hypothesis that the hyperlipidemic response to isotretinoin is genetically determined and that isotretinoin unmasks the genetic predisposition of some individuals to develop FCHL or a component of the metabolic syndrome.

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