Leg ulcers can reveal systemic diseases such as connective tissue diseases, infections, or cryoglobulinemia.1-3 The objectives of this study were to record the clinical features of leg ulcers associated with cryoglobulinemia, to identify any correlation between the clinical outcome of the wounds and the biologic indexes, and to review the different effective treatments.
Auzerie V, Chiali A, Bussel A, et al. Leg Ulcers Associated With Cryoglobulinemia: Clinical Study of 15 Patients and Response to Treatment. Arch Dermatol. 2003;139(3):391–393. doi:10.1001/archderm.139.3.391
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