Dr Smoller has accomplished a concise book that contains much of the current knowledge on practical immunohistochemistry applied to skin pathology.
The book is organized in an introduction, a directory of antibodies, and a series of vignettes. The introduction has a short overview on how and when immunohistochemistry should be performed. Dr Smoller indicates some very important points in this overview, eg, the need of supervision by a qualified physician such as a surgical pathologist or a dermatopathologist. Interpretation of immunohistochemical slides requires correlation with external and internal controls, and with clinical information. Dr Smoller stresses the fact that immunohistochemistry by itself cannot establish a diagnosis of malignancy or benignity in a specimen. The introduction also contains a very informative description of immunohistochemistry that includes methodology and a discussion of possible pitfalls in the interpretation of immunohistochemical slides, such as the distinction of cytoplasmic vs nuclear expression depending on the particular antibody.
Prieto VG. Practical Immunopathology of the Skin. Arch Dermatol. 2004;140(2):247. doi:10.1001/archderm.140.2.247-a
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