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February 2004

Kinetics and Specificity of Fas Ligand Induction in Toxic Epidermal Necrolysis

Arch Dermatol. 2004;140(2):242-244. doi:10.1001/archderm.140.2.242

Toxic epidermal necrolysis (TEN) is a severe drug-induced bullous eruption that has significant mortality and morbidity.1 Induction of Fas ligand, a cytokine that induces apoptosis, may mediate cell death in TEN in part because the soluble Fas ligand (sFasL) level is elevated in the blood of patients with TEN.2 Pooled human immunoglobulin blocks the action of Fas and may be beneficial in TEN.2 The kinetics and specificity of sFasL induction in TEN and other bullous dermatoses are unknown. We present preliminary results of serial sFasL measurement in a patient with TEN and 10 patients with 5 types of chronic bullous diseases.