The dermatology consultation service was asked to evaluate a 3-year-old African American boy with a 1-day history of numerous vesicles on his trunk and in intertriginous folds. He had a history of sickle cell disease and had been admitted to the pediatric intensive care unit for treatment of acute chest syndrome. He was febrile and on a multidrug regimen, including erythromycin, cefotaxime sodium, vancomycin hydrochloride, fentanyl citrate, and famotidine. The rash developed rapidly during his hospital stay.