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Evidence-Based Dermatology: Research Commentary
March 2004

A Randomized Controlled Trial of Methotrexate and Cyclosporine in the Treatment of Psoriasis

Arch Dermatol. 2004;140(3):347-348. doi:10.1001/archderm.140.3.347

Commentary on: Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis

Heydendael VM, Spuls PI, Opmeer BC, et al

N Engl J Med. 2003;349:658-665

Question: In patients with chronic plaque psoriasis, does treatment with cyclosporine or methotrexate lead to higher rates of clearance,and what toxic effects are associated with each treatment?

Design: Heydendael and colleagues conducted a randomized controlledtrial comparing the effectiveness and side effects of methotrexate and cyclosporineand the quality of life they provide.

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