Commentary on: Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis
Heydendael VM, Spuls PI, Opmeer BC, et al
N Engl J Med. 2003;349:658-665
Question: In patients with chronic plaque psoriasis, does treatment with cyclosporine or methotrexate lead to higher rates of clearance,and what toxic effects are associated with each treatment?
Design: Heydendael and colleagues conducted a randomized controlledtrial comparing the effectiveness and side effects of methotrexate and cyclosporineand the quality of life they provide.