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March 2004

Multiple Asymptomatic Nodules in an African American Boy—Diagnosis

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Arch Dermatol. 2004;140(3):353-358. doi:10.1001/archderm.140.3.353-d

Light microscopic examination of the biopsy specimen revealed irregular epidermal hyperplasia associated with a dermal proliferation consisting ofaggregates of cells demonstrating a predominantly lobular growth pattern The constituent round and polyhedral cells were monotonous, with abundant eosinophilicgranular cytoplasm and distinct cell borders. Some cells demonstrated pustulo-ovoid bodies of Milian in the cytoplasm (Figure3). The nuclei were typically centrally placed, small, and often slightly hyperchromatic with inconspicuous nucleoli. Mitotic figures wereabsent.

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