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March 2004

Localized Facial Macules and Vesicles—Diagnosis

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Arch Dermatol. 2004;140(3):353-358. doi:10.1001/archderm.140.3.353-h

Direct immunofluorescence of the biopsy specimen from nonlesional skin revealed granular deposition of IgA concentrated at the dermoepidermal junction.The patient's hemoglobin levels had decreased over the past year to as low as 10.3 g/dL (reference range, 12.0-15.5 g/dL), with a hematocrit of 34% (referencerange, 35%-45%) and a ferritin value of less than 2 ng/mL (reference range, 15-290 ng/mL). Serum chemistry studies and liver function tests revealed noabnormalities. Antigliadin IgG and IgA antibody levels were markedly elevated.