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May 2004

Adjacent Dermal Nodules on the Nose—Diagnosis

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Arch Dermatol. 2004;140(5):609-614. doi:10.1001/archderm.140.5.609-d

The microscopic appearance of both nodules was similar. Histologic analysis showed a benign skin appendage tumor that was composed of well-circumscribed nodules situated within the dermis (Figure 2). The nodules were partly solid and partly cystic. The solid areas consisted of cells with small regular nuclei. Mitoses were very frequent. Focal ductal differentiation was present (Figure 3). Immunhistochemical studies showed focal positive staining for CAM 5.2, epithelial membrane antigen, cytokeratin 7, and cytokeratin 19.

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