Dramatic advances in biotechnology are revolutionizing medical science. Recent discoveries in molecular biology, genomics, cellular and tissue engineering, new drug discovery techniques, and bioimaging hold the promise of improving medical care by enhancing diagnostic capabilities and substantially expanding therapeutic options.1 To increase the awareness of physicians, other health care professionals, and clinical researchers about cutting-edge advances and promising recent discoveries in this dynamic and rapidly evolving research area, the Archives of Dermatology, JAMA, and other ARCHIVES journals will publish a theme issue devoted to medical applications of biotechnology in early 2005.