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Off-Center Fold
June 2004

Rhinophymalike Swelling in an 86-Year-Old Woman—Diagnosis

Author Affiliations


Arch Dermatol. 2004;140(6):751. doi:10.1001/archderm.140.6.751-h

Sections of skin showed a dense and diffuse dermal infiltrate of small atypical lymphocytes (Figure 2). Epitheliotropism was not seen. Immunohistochemically, the majority of the cells marked as B lymphocytes (CD20 positive), with a lesser number of individually scattered T lymphocytes (CD3 positive). The cells diffusely expressed bcl-2 protein. Occasional lymphocytes expressed bcl-6 protein, and the cells were immunonegative for CD5, CD10, and κ and λ chains. An immunoglobulin heavy-chain gene rearrangement was detected by polymerase chain reaction. These histopathologic, immunophenotypic, and molecular findings were consistent with B-cell lymphoma of follicle center origin.