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August 2004

Asymptomatic Nodule on the Lower Eyelid—Diagnosis

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Arch Dermatol. 2004;140(8):1003-1008. doi:10.1001/archderm.140.8.1003-f

Light microscopy showed evidence of multiple nodular masses of basaloid cells with peripheral palisading. Nodular masses showed little melanin within the nodules but many melanophages in the connective tissue stroma surrounding tumor masses.

Basal cell carcinomas are the most common cutaneous tumors, accounting for approximately 70% of all malignant diseases of the skin, exceeding squamous cell carcinomas by a ratio of 5:1. They are found on sun-exposed areas (the head and neck region accounts for 80% of cases) and are more common in whites, being rare in blacks.1 They are also more common in males than in females, presumably because males have greater occupational and recreational exposure to UV light. Other predisposing factors are exposure to radiation and genetic and hereditary disorders.1 Basal cell carcinomas tend to occur in older persons but have been documented in children.