In lymphatic leukemia occasionally there are found lymphadenotic infiltrations in the skin and subcutaneous tissues that are a part of the general disease. These infiltrations consist of hyperplastic lymphocytic elements and are generally supposed to be marrow lymphocytes transported by the blood stream and deposited in the skin and subcutaneous tissues. These lymphadenotic skin changes occurring in, or preceding, a lymphatic leukemia are of two forms: the circumscribed, or tumor, and the diffuse, or universal. The first is a nodular, or tumor form, or a circumscribed leukemic, or aleukemic, lymphadenosis of the skin. The second is a diffuse or universal leukemic, or aleukemic, lymphadenosis of the skin. Sometimes we find generalized skin affections, as purpura, prurigo, urticaria, pruritus and generalized exfoliative dermatitis, associated with or preceding a leukemic condition. The differentiation of this group of affections from like processes in no way related to a leukemia is impossible by means
BUTLER J. LYMPHATIC LEUKEMIA WITH PRIMARY MANIFESTATIONS OF THE SKIN. Arch Derm Syphilol. 1920;2(5):594–606. doi:10.1001/archderm.1920.02350110069004
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