The earliest studies of Schaudinn and Hoffmann1 pointed to a rapid invasion of the lymphatic glands by Spirochaeta pallida. Metchnikoff and Roux2 and Finger and Landsteiner3 were able to inoculate animals with lymph glands taken early in the course of infection. It was not until later that evidence was shown that in the absence of a primary lesion, spirochetes could be found in the circulation. For this discovery we are indebted to Reasoner,4 who, in 1916, demonstrated a generalized infection in rabbits from which the inoculated testicles had been removed before an initial lesion had fully developed. The obvious deduction from this study is that the dissemination of spirochetes occurs very early in the disease and that the primary focus of infection is not a measure of any subsequent reaction in the animal. Indeed, Reasoner found by experiment that the blood serum of an intratesticularly inoculated
EBERSON F. DISSEMINATION OF SPIROCHAETA PALLIDA IN EXPERIMENTAL SYPHILIS. Arch Derm Syphilol. 1921;3(2):111–116. doi:10.1001/archderm.1921.02350140003001
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