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Article
June 1921

XXIII.—IMMUNITY STUDIES IN EXPERIMENTAL SYPHILIS: INFECTIVITY AND SURVIVAL OF SPIROCHAETA PALLIDA IN RABBITS, WITH OBSERVATIONS ON SOME STRAINS FROM LATENT SYPHILIS

Author Affiliations

Associate in Dermatology, Washington University School of Medicine St. Louis

Arch Derm Syphilol. 1921;3(6):775-787. doi:10.1001/archderm.1921.02350190056006
Abstract

Local immunity, or a better term, resistance to reinoculation in syphilis has been established as a fact both experimentally and clinically. Information is lacking with regard to the behavior of Spirochaeta pallida which have been exposed to such influences as might logically be assumed to modify the course of an infection in the animal body. It has been shown in a previous study1 that syphilis in man, when latent and outwardly inactive, can be associated with the presence of Spirochaeta pallida in the glands and in the semen. In the experimental animal this question has been approached as a control on the problem in man, and results, such as localization in certain glands and preliminary observations bearing on latency in experimental syphilis, have been recorded in another place.2 The brilliant studies of Brown and Pearce3 which were made in connection with the therapeutic action of drugs have

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