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The second edition of this work incorporates within its pages a considerable amount of material which is new. About 400 pages have been revised and rewritten and a description of fifteen new diseases has been added. The references to the literature have, so far as it is possible, been brought up to date, the author having made a fruitful effort to include references to selected papers and monographs containing full bibliographies to the date of publication. To one who is accustomed to grapple with the task of looking up references, the value of such a procedure will be obvious, for a great deal of time and toil may be saved by getting hold of a single up-to-date bibliography, instead of wading through a maze of references which antedate the more recent publications. More space may thus be utilized for the text itself, to say nothing of illustrations, which indisputably are