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August 1921


Author Affiliations

Instructor in Dermatology and Syphilology, University of Minnesota; Voluntary Assistant in the Night Clinic for Syphilis MINNEAPOLIS

Arch Derm Syphilol. 1921;4(2):184-192. doi:10.1001/archderm.1921.02350210047006

Sodium arsphenamin was introduced in the early part of 1915 and was used in large quantities in Germany. Favorable reports have been made by Dreyfus,1 Fabry and Fischer,2 Gutmann,3 Hoffmann,4 Loeb,5 Seyfarth,6 Wechselmann,7 Brandweiner,8 Hirsch,9 Schmitt,10 Ylppö11 and Glombitza.12

LITERATURE  With the exception of one preliminary report,13 all of the literature on this subject is confined to the German.Dreyfus,1 in 1915, reported on the results of 450 injections. He used the drug in combination with mercury in cases of cerebrospinal syphilis and obtained good results. He rarely gave over 0.45 gm.Fabry and Fischer,2 after using various doses and dilutions, decided that from 0.3 gm. to 0.6 gm. (average, 0.45 gm.) in 50 c.c. of water was the best dosage. They thought the drug could be used in more concentrated solution. They gave from

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