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Article
August 1921

A REVIEW OF THE LITERATURE AND A DISCUSSION OF SILVER ARSPHENAMIN

Author Affiliations

Instructor in Dermatology, University of Minnesota; Voluntary Assistant, Night Syphilis Clinic, University of Minnesota MINNEAPOLIS

From the Department of Dermatology and Syphilology, University of Minnesota, Minneapolis.

Arch Derm Syphilol. 1921;4(2):193-206. doi:10.1001/archderm.1921.02350210056007
Abstract

Silver arsphenamin, the latest of the arsphenamin series of drugs, is now on the market, and is being used in America. There is no English literature to guide one in determining its qualities. Our communication is an effort to review the literature on silver arsphenamin and to draw conclusions therefrom.

Silver arsphenamin was suggested by Ehrlich, whose untimely death cut short his researches, which were continued by Kolle who finally elaborated silver arsphenamin. This drug was first used clinically in March, 1918.

Kolle,1 in 1918, in the first of a series of articles, gives the following table which shows that silver arsphenamin had a more profound effect on experimental syphilis than any of the other members of the arsphenamin group. He concludes from his work that silver when combined with the arsphenamin molecule forms a combination which has a greater spirocheticidal action than other combinations with which he worked.

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