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Professor Bosellini has written a unique book. We do not know of any other treatise in the dermatologic literature covering so thoroughly and so scientifically the subject of the relation of internal disorders to dermatology. The first two chapters are dedicated to the anatomy and physiology of the skin, and these subjects are treated in detail. A special point is made of the description of the nervous system, particularly of the sympathetic. The third and fourth chapters deal with the pathologic anatomy and etiology of skin diseases, respectively. The second part of the book is the most important. It is dedicated to the study of the pathologic relations between the different organs and apparatus of the body and the skin. Professor Bosellini discusses the metabolism of fats in its relations to such diseases as xanthoma and seborrhea, the metabolism of carbohydrates and that of proteins and inorganic materials. Xanthoma is