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Article
October 1921

REFRACTOMETRIC STUDIES IN HUMAN SYPHILIS WITH SPECIAL REFERENCE TO CHANGES DURING TREATMENT WITH ARSPHENAMIN AND NEO-ARSPHENAMIN

Author Affiliations

PHILADELPHIA

From the Dermatological Research Institute and the Wistar Institute of Anatomy, Philadelphia.

Arch Derm Syphilol. 1921;4(4):512-525. doi:10.1001/archderm.1921.02350230101006
Abstract

INTRODUCTION  The refractometric studies with the proteins of the serum in syphilis reported in this article were undertaken at the suggestion of Prof. John A. Kolmer as primarily bearing on the nature of the serum changes in this disease in relation to immunologic phenomena and as possibly yielding additional information as to the mechanism of the "reactions" sometimes developing after the intravenous injection of solutions of arsphenamin and neo-arsphenamin.1 Various hypotheses have been advanced in explanation of these "reactions," among which those based on the formation of precipitates in vivo have attracted considerable attention. Berman2 believes that precipitates may be produced because of the presence of an excess of serum globulins in the plasma, and advocates a simple test for determining whether or not the serum of a patient produces precipitates with alkalinized solutions of arsphenamin in vitro.Schamberg, Tokuda and Kolmer,3 however, found that the test

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