In 1889, Darier brought to our attention an unusual skin manifestation which was characterized by the occurrence of a follicular keratosis with a peculiar histopathologic picture, a more or less generalized distribution and associated lesions of the mucous membranes. Since then many cases similar in all respects to this original description have been reported, most of them however having been observed in young or old adults, a search through the literature revealing no detailed description of its onset in an infant. This case seemed to be of interest, not only because of its skin picture and early presentation, both as to age and date of onset, but particularly because of the presence of unusual mucous membrane lesions.
REPORT OF CASE
R. S., a male child of 27 months, born of American parents on a farm in southern Illinois, was first seen at the office of Dr. M. F. Engman
BORGHOFF JA. XXV.—DARIER'S DISEASE IN THE INFANT. Arch Derm Syphilol. 1921;4(5):609–615. doi:10.1001/archderm.1921.02350240050003
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