In a previous publication1 the following changes were observed in the serums of syphilitic patients during the course of eight intravenous injections of arsphenamin (from 0.4 to 0.6 gm.) and neo-arsphenamin (0.9 gm.), each drug being given at weekly and semiweekly intervals.
Classified according to the Wassermann reaction of the serums before treatment, there were no sufficiently constant or striking differences to warrant differentiating between the strongly and the weakly positive series.
Considered according to the intervals of injection, the relative amounts of globulins showed more rapid decline during weekly arsphenamin than during neo-arsphenamin injections.
During semiweekly periods of administration, the changes were about the same.
Classified according to the degree of resistance of the patients to antisyphilitic treatment (as indicated by repeated Wassermann tests) it was observed that when the Wassermann reaction remained persistently positive, the refractive index, the percentage of total proteins and the