The combination of refractometry and viscosimetry apparently can be used for the determination of the albumin-globulin ratio in blood serum.
Globulin is in some way associated with the process of immunity, though perhaps only in an incidental way. The Nonne test of the spinal fluid is based entirely on the presence of the globulin. A relation of other tests to globulin is at least suspected. While an increase of globulin in blood serum is not specific for any disease, there may at least be a quantitative relationship to pathologic processes. Hence it would seem that its presence or absence in the body fluids might prove to be of diagnostic significance. Syphilitic blood serum has been chosen for this investigation because it is known to present an increased globulin content. Our study is far from being complete, but the results seem to be sufficiently interesting to warrant a report at this
BIRCHER ME, MCFARLAND AR. THE GLOBULIN CONTENT OF THE BLOOD SERUM IN SYPHILIS. Arch Derm Syphilol. 1922;5(2):215–233. doi:10.1001/archderm.1922.02350270056005
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