In 1919, Darier1 published an article on the vesicular and the vesicopustular eruptions on the hands and feet. In this article, he found mycelia, on microscopic examination, in the majority of those conditions corresponding to the classic description of pompholyx. His conclusions were that, after excluding eruptions of dermatitides due to plants, trauma, trades and the streptostaphylococci (dematitis venenata; dermatitis traumatica; occupational dermatitis, and infectious eczematoid dermatitis), most cases of pompholyx (80 per cent.) were of mycotic nature.
The opinion expressed by Darier in 1919 created widespread interest. This opinion has not, however, been generally accepted up to the present time by independent observers, because of the general failure to demonstrate mold fungi in the typical lesions of pompholyx. As a matter of fact, Darier, in a most recent expression of opinion,2 stated that he found parasitic mycelia in 80 per cent, of those cases presenting the clinical
GREENBAUM SS. INOCULATION, AUTOINOCULATION AND COMPLEMENT FIXATION TESTS IN POMPHOLYX (TILBURY FOX). Arch Derm Syphilol. 1922;6(6):757–760. doi:10.1001/archderm.1922.02360060102009
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