Numerous flocculation or precipitation tests have been described for the serum diagnosis of syphilis. These have had their origin in the fundamental studies of Moreschi and Gay on the subject of protein precipitation in relation to the phenomenon of complement fixation, and about fifteen years ago Michaelis1 showed that in mixtures of serum from a syphilitic person and "antigen" commonly employed in the Wassermann test, a flocculent precipitate may develop, when the reaction is positive. Since then numerous attempts have been made to develop a diagnostic test for syphilis along these lines, as a simple substitute for the more complex complement-fixation test. The tests of Porges and Meier,2 Herman and Perutz,3 were among the earliest to command attention, but failed to prove of diagnostic value. Within the last few years, interest in the subject has been renewed, especially by the methods of Meinicke, Sachs and Georgi, Vernes,
STRUMIA MM. A STUDY OF SERUM FLOCCULATION REACTIONS IN SYPHILIS WITH SPECIAL REFERENCE TO THE MEINICKE, SACHS-GEORGI, KAHN AND VERNES REACTIONS. Arch Derm Syphilol. 1923;8(1):50–62. doi:10.1001/archderm.1923.02360130053007
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