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Article
October 1923

THE USE OF CHROMOGENIC INDICATORS IN DERMATOLOGY

Author Affiliations

NEW YORK

From the Harriman Research Laboratory, Roosevelt Hospital, and the Vanderbilt Clinic, Department of Dermatology and Syphilology, College of Physicians and Surgeons, Columbia University.

Arch Derm Syphilol. 1923;8(4):515-519. doi:10.1001/archderm.1923.02360160057008
Abstract

One of us (H. S.) in collaboration with Scheer,1 estimated, with the aid of chromogenic indicators, the hydrogen-ion concentration of the surface of the skin. For the sake of clarity and as a necessary introduction to the subject matter of this report, we must repeat some of the statements and facts discussed therein.

Many dyes pass through a range of colors when applied to solutions of proper hydrogen-ion concentration. Such compounds may be used as indicators of hydrogen-ion concentration, each compound being of use for only that span on the scale of concentration within which the complete range of colors of the compound can be produced. It is therefore necessary for colorimetric estimations of hydrogen-ion concentration to choose the indicators suitable for the substance to be tested.

In the investigation of the hydrogen-ion concentration of the skin surface, three indicators were used: (1) brom phenol blue, 0.04% in alcohol;

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