The increasing sensitivity of the Wassermann reaction has caused in recent years much speculation and research in the rôle played by cholesterin. Henes1 has raised the question: Are not the Wassermann results affected by the fluctuation of the cholesterin in the serum? From the results of his work he seems to favor that conclusion.
It occurred to us that if cholesterin in the serum played a part in the reaction, this fact could be brought out by doing serial Wassermann tests and parallel cholesterin determinations on many patients. Then, on tabulating the results, any correlation between the variations in the cholesterin content and the degree of fixation in the Wassermann test could be observed.
This was accordingly attempted on ninety-one patients, thirty-three nonsyphilitic patients and fifty-eight syphilitic patients. It was impossible to make serial determinations on all of the patients, but it will be observed that two or more
WEISS RS, ESSERMANN AL. XXXIII.—THE RELATIONSHIP BETWEEN SERUM CHOLESTERIN AND THE WASSERMANN REACTION. Arch Derm Syphilol. 1923;8(5):639–646. doi:10.1001/archderm.1923.02360170044006
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