The author presents an excellent and comprehensive monograph in which the material is drawn from personal experience and a liberal reference to German literature. It is intended to simplify and to teach in minute detail the diagnostic phases of this subject to the student and to correct errors in technic and observation commonly committed by specialists as well as by general practitioners. While chiefly of value to the laboratory worker, the text is replete with observations and deductions of importance to the clinician. Twelve of the twenty-one chapters are of special interest to the syphilographer. Nine pages deal with anatomic and physiologic considerations; seventeen with the technic, dangers and sequelae of puncture; nineteen with the theory, technic and clinical data of the colloidal gold reaction; thirteen with the Wassermann reaction; nineteen with the diagnostic and prognostic significance and eight with the therapeutics of lumbar puncture. Considerable attention is devoted to