A perusal of the literature reveals a tendency by most authors to utilize the term "erythema dose" as a quantitative unit in radium dosage. Such terminology is convenient but lacks definition, as evidenced by the wide range of dosage that is interpreted as the erythema dose. Standardization is rendered difficult as the skin of different parts of the body and of different persons reacts differently to equivalent applications; furthermore, different types of applicators entailing variations in the shape and area of the source of radiation, as well as variations in the quantity of radium used and the type and quantity of filtration, complicate the problem. Using tubes, plaques and needles a series of experiments were performed during several years in an attempt to gain some definite information bearing on the erythema dose. As will be mentioned later, the difficulties in estimating this unit on skin surfaces are almost insurmountable; so
GUY WH, JACOB FM. THE ERYTHEMA DOSE OF RADIUM. Arch Derm Syphilol. 1924;9(1):73–81. doi:10.1001/archderm.1924.02360190076005
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