The study of the functions of the skin is fundamentally a most complex problem. We are dealing with an organ spread out in a thin sheet over a large area with an extremely compact arrangement of heterogeneous elements. Metzner1 has rightly said: "The many-sidedness of the tasks which every section of the skin has to fulfill brings it about that in this thin covering the most varied apparatus are crowded together and interwoven with one another in the smallest space, a circumstance which naturally makes very much more difficult the clearing up of the mechanism participating in the individual functions." The elemental processes of the skin are founded on the intricate mechanism of cell metabolism, with its innumerable checks and balances, and its responses to a multitude of diverse, almost infinitesimal stimuli. These are biochemical problems to be solved by studies in the borderland of both physiology and chemistry,
LANE CG. NEWER PHYSIOLOGY OF THE SKIN: WITH SPECIAL REFERENCE TO THE ACTION OF ULTRAVIOLET LIGHT. Arch Derm Syphilol. 1924;9(2):176–186. doi:10.1001/archderm.1924.02360200032002
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