During the last two decades great progress has been made in syphilology, and nearly every advance has been one which greatly improves the opportunity to deal successfully with early syphilis. The discovery of the spirochete has made it possible to identify positively the initial lesion; the Wassermann test has assisted in judging the time of the general dissemination of the disease, and arsphenamin has given us a powerful agent to render the disease noninfectious quickly, if not to cure it completely.
For several years after the achievements mentioned, efforts were devoted toward establishing a standard of treatment, and every year brought changes either in technic or in methods. During the last three or four years, however, there has been fairly general agreement on methods of treatment. It is the purpose of this paper to call attention to new drugs and methods and to attempt to outline the generally accepted methods
IRVINE HG. TREATMENT OF EARLY SYPHILIS. Arch Derm Syphilol. 1924;9(2):231–241. doi:10.1001/archderm.1924.02360200087006
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