During an investigation of the Wassermann test as a criterion of cure for syphilis, it became necessary to compile data as to the effect of various antisyphilitic remedies on the Wassermann reaction. Among the drugs thus used was mercurosal,† a synthetic compound of mercury, di-sodium-hydroxymercuri-salicyl-acetate, This paper studies influence HgOH presents our studies on the influence of mercurosal in the treatment of serum positive syphilis.
A good antisyphilitic drug must fulfil four requirements: (1) ease and convenience of administration; (2) no toxic effect on the patient; (3) the production of clinical improvement, and (4) the reduction of a positive Wassermann reaction. It is our purpose to record our findings with mercurosal in respect to these four qualifications, with special consideration of the last. By so doing we do not place ourselves on record as advocating any special compound since, in our opinion,
BELDING DL, HOLMES RH. THE WASSERMANN TEST: XI. THE EFFECT OF MERCUROSAL ON THE WASSERMANN REACTION. Arch Derm Syphilol. 1924;9(4):459–469. doi:10.1001/archderm.1924.02360220039004
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