Sulpharsphenamin has recently been featured in the treatment of syphilis. Several commercial preparations are now on the market, and the attention of physicians is frequently called to its superiority over the other arsphenamin preparations. It is the tendency of the medical profession to minimize the shortcomings and to overemphasize the advantages of a new remedy, and such sulpharsphenamin may be considered, although it has been used in Europe since 1919. It is my purpose to point out certain dangers which may arise from its careless use, particularly since toxicity tests in animals are not a safe guide for clinical administration.
In a study of the influence of sulpharsphenamin on the Wassermann reaction, the clinical results were observed in forty-four adults and nineteen children. In order that its complete serologic effect might be obtained, the drug was administered regularly and frequently, giving a higher weekly rate than in routine clinical practice,
BELDING DL. THE WASSERMANN TEST: XII. SULPHARSPHENAMIN IN THE TREATMENT OF SYPHILIS. Arch Derm Syphilol. 1924;9(4):470–478. doi:10.1001/archderm.1924.02360220050005
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