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April 1924


Arch Derm Syphilol. 1924;9(4):538-539. doi:10.1001/archderm.1924.02360220118013

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CONGENITAL PORPHYRINURIA. Dr. Mobitz.  Since the second year of his life the patient had had a dark red urine with a high content of porphyrin. Every summer he had had an attack of hydroa aestivale. The entire body was brown; it became darker during the summer. During the last few years there had been pronounced anemia, the spleen being enlarged down to the umbilicus.In the discussion, the acute form of porphyrinuria was distinguished from the chronic type. The former generally affects women from 20 to 30 years of age. It is characterized by sudden pain in the epigastrium and an immediate permanent filling of the enlarged duodenum with the bismuth meal shown by roentgenogram. This form is frequently provoked by a prolonged medication of sulphonemethane and sulphonethylmethane. There is no susceptibility to light. Repeated attacks frequently lead to lethal paralysis. Chronic porphyrinuria generally develops in advanced age. There is

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