Modification and variations in the technical details of the serologic test for syphilis originally described by Wassermann have been so numerous and so varied that the phrase "Wassermann test" is about all that remains of the original method.
In spite of the numerous refinements of technic which have been developed and which have added much to the delicacy and reliability of the procedure, the new methods, in the main, have still one thing in common with the old—most of them are merely, in essence, rough qualitative tests serving to detect merely the presence or absence of syphilitic reagin and permitting, at best, only a relative and more or less empirical estimation of the amount of reagin present as gaged by the Citron scale. The personal equation, impossible to avoid or to compensate for, renders such estimations extremely unsatisfactory and subject to individual variations of varying degree.
It seems odd that
KILDUFFE RA. THE CASE FOR AND AGAINST THE QUANTITATIVE COMPLEMENT-FIXATION TEST IN SYPHILIS. Arch Derm Syphilol. 1924;9(5):571–576. doi:10.1001/archderm.1924.02360230029004
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