Meinicke,1 Sachs and Georgi,2 Dreyer and Ward,3 and Wang4 have all been instrumental in developing precipitation tests for syphilitic diagnosis. We can readily see the advantage of such methods over the Wassermann test, since they do away with the intricacy and tediousness of the Wassermann technic. These precipitation methods omit amboceptor, complement and blood cells; all that is necessary is to mix the serum to be tested with suitable antigen and wait until a precipitation occurs. In nonsyphilitic serums, no precipitation occurs.
However, all these precipitation methods have their faults and cannot replace the Wassermann test. Some give falsely positive results with nonspecific serums, while others give slight precipitates with strongly positive serums and negative results with weakly positive serums. Others are too complicated for the routine worker. These difficulties make these precipitation methods of doubtful value to the serologist.
This was true until in May,
ISHII O. COMPARATIVE STUDIES ON THE KAHN PRECIPITATION TEST FOR SYPHILITIC SERUM AND THE WASSERMANN TEST. Arch Derm Syphilol. 1924;9(5):612–620. doi:10.1001/archderm.1924.02360230072011
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