Alderson,1 in 1922, reported a case of severe onychauxis of the finger and toe nails in a woman aged 49 years, with disappearance of the condition in the course of ten months under the administration of thyroid extract. The case report that follows concerns a young man who suffered unmistakably from eunuchoidism, due to trauma and subsequent sloughing and atrophy of the testicles. He presented obvious onychauxis of finger and toe nails as may be seen in the illustrations; and a similar transformation occurred with disappearance of the condition by supplementing the gonad deficiency with subcutaneous implantations into the abdominal wall of fresh unextracted, untreated ram's testicular substance. Hypothyroidism, hypopituitarism and hypogonadism (whether ovarian or testicular) are often accompanied by more or less profound trophic disturbances of the skin, subcutaneous tissues, hair, teeth and nails. It is not altogether surprising, therefore that a proper replacement therapy will frequently ameliorate
LISSER H. ONYCHAUXIS IN A EUNUCHOID: REMARKABLE IMPROVEMENT BY IMPLANTATIONS OF TESTICULAR SUBSTANCE. Arch Derm Syphilol. 1924;10(2):180–182. doi:10.1001/archderm.1924.02360260043004
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