In 1906, Wassermann described the complement-fixation test for the serum diagnosis of syphilis. Soon after the publication of his work, many workers attempted to diagnose syphilitic serums by means of a precipitation method. Most of these early workers had little success, rarely obtaining reliable results.
Since 1917, Meinicke,1 Sachs and Georgi,2 Dreyer and Ward,3 Wang,4 and Kahn5 have advocated much more reliable methods for the precipitation reaction of syphilitic serums. But in using these methods, pseudoreactions were often obtained; falsely positive reactions were obtained with negative serums and negative reactions occurred with positive serums. Other methods proved too complicated for routine work. Kahn, in this country, devised a simple method which has given accurate results, checking up well with clinical findings. Many workers find it more reliable than the Wassermann test, so that this method is assuming a prominent place in the diagnosis of syphilis.
ISHII O. ANTIGEN FOR PRECIPITATION TEST WITH SYPHILITIC SERUMS. Arch Derm Syphilol. 1924;10(2):203–208. doi:10.1001/archderm.1924.02360260066006
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