Many authors have advocated the use of the precipitation reaction with spinal fluid in the diagnosis of syphilis.
In Kahn's technic,1 1 c.c. and 1.5 c.c., respectively, of spinal fluid are placed in each of two test tubes, and to each is then added 0.1 c.c. of dilute antigen. This antigen consists of one part of the antigen which Kahn advocates for use in the precipitation test for syphilitic serum and three parts of physiologic sodium chlorid. The tubes are then thoroughly shaken, and allowed to stand for several hours or until precipitation occurs. He claims favorable results for this method in comparison with the Wassermann reaction and clinical findings. Many workers, among whom are Detweiler,2 Moody,3 Ide and Smith,4 and Grant,5 have since reported unfavorable results on trying to repeat this work. On the other hand, Anderson and Fisher6 have reported favorable reactions
ISHII O. THE PRECIPITATION TEST ON SPINAL FLUID IN SYPHILIS. Arch Derm Syphilol. 1924;10(4):442–445. doi:https://doi.org/10.1001/archderm.1924.02360280036006
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