Since the discovery that "antigen" extracts for the conduct of complement-fixation tests in syphilis need not be made from spirochetaecontaining syphilitic organs, and that alcoholic extracts of indifferent and nonsyphilitic organs or tissues were not only quite suitable but, in fact, superior for the purpose, a great deal of time and study have been devoted to the determination of what constitutes the most satisfactory extract.
The merits and demerits of the numerous technical modifications introduced by various workers into the technic of the complementfixation test in syphilis are surrounded and involved in a maze of discussion, but if there is any one point on which serologists may be found in entire and unanimous accord, it is on the essential and vital necessity for the use of a suitable antigen. On this one factor and this single reagent, the delicacy, reliability and specificity of the reaction are in no small measure
KILDUFFE RA. STABILITY OF DESICCATED BEEF HEART MUSCLE POWDER FOR PREPARATION OF ANTIGENS FOR CONDUCT OF COMPLEMENT-FIXATION TESTS IN SYPHILIS: WITH SPECIAL REFERENCE TO THE KOLMER METHOD. Arch Derm Syphilol. 1924;10(6):734–744. doi:10.1001/archderm.1924.02360300068005
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