The presence of natural antisheep amboceptor in human serums in perceptible and even at times large amounts has been demonstrated by numerous investigators, and its relation to the use of an antisheep hemolytic system in the performance of complement-fixation tests for syphilis has been widely commented on.
While there are many who feel that the quantitative relations of an antisheep hemolytic system are so gravely disturbed by the frequent presence of unknown amounts of natural antisheep hemolysin in the serum to be tested as to interfere with the detection of small amounts of syphilitic reagin, and who, therefore, deem their removal a prerequisite for the performance of the test, there are also those who feel that the question has, perhaps, a greater theoretical than practical importance.
The literature concerning the question is rather voluminous, and many authorities can be cited on both sides of the question.
The conclusions to be
KILDUFFE RA. RELATION OF NATURAL ANTISHEEP HEMOLYSIN OF HUMAN SERUMS TO KOLMER'S QUANTITATIVE COMPLEMENT-FIXATION TEST FOR SYPHILIS. Arch Derm Syphilol. 1924;10(6):745–753. doi:10.1001/archderm.1924.02360300079006
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