The results of the routine application of the Kolmer1 quantitative method to the blood of each admitted patient, together with the history and complete physical examination, were reported about one year ago.2
Up to that time 3,300 parallel tests had been made, using a 0.2 per cent. cholesterinized alcoholic extract of human heart as an antigen with four-hour icebox fixation (8 C.).
Although the Kolmer quantitative method was adopted at this time for our reports, the cholesterinized antigen and icebox fixation was selected as a routine check test, first, because a second antigen seemed advisable from the standpoint of clerical and technical errors, and second, because in the short series it was more sensitive than the Kolmer and in some instances rightly so; in others, it gave definitely false positives.
Available reports are to a certain extent at variance as to the advisability of using a cholesterinized antigen
REYNER CE, HARTMAN FW. THE KOLMER COMPLEMENT FIXATION AS A SPECIFIC TEST FOR SYPHILIS. II. Arch Derm Syphilol. 1925;11(1):91–94. doi:10.1001/archderm.1925.02370010104006
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