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September 1925

THE WASSERMANN TESTXV. THE EFFECT OF BISMUTH ON THE WASSERMANN REACTION IN PATIENTS UNRESPONSIVE TO ARSPHENAMIN

Arch Derm Syphilol. 1925;12(3):334-344. doi:10.1001/archderm.1925.02370090011002
Abstract

Several hundred references in recent medical literature testify to a widespread interest in the treatment of syphilis with bismuth compounds. The trend of clinical evidence indicates that these drugs are especially valuable in the treatment of patients who do not respond to arsphenamin and mercury. I shall consider the effect of bismuth on the Wassermann antibody in the so-called Wassermann-fast patients, who do not respond serologically to arsenic and mercury.

METHODS OF WORK  The method of measuring the strength of the Wassermann antibody described in a previous paper1 was followed. Determinations were made before, halfway through, and at intervals of four weeks over a period of twenty-four weeks after the completion of treatment.

Bismuth.—  Three compounds of bismuth suspended in oil were administered by gluteal injection: (1) iodobismuthate of quinin; (2) a bismuthyl compound of an oxybenzoic acid, and (3) potassium bismuth tartrate with butyn. The iodobismuthate of quinin,

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